Mamani graduated with a law degree from Arturo Prat University and has credited her education with giving her the tools she needed to advocate for her people.

[5] Following her election to the Constitutional Convention in 2021, Mamani embarked on a seven-day journey from Alto Hospicio to Santiago, where the body is located.

You always have to respect that.” During her week-long trip to Santiago, she stopped in Colchane to "receiv[e] the blessing from the caciques", and visited other areas of ancestral importance to the Aymara people.

This request was declined by Executive Secretary of the Administrative Secretariat Francisco Encina, who defended his decision on the basis of logistical issues.

We want this to not be the case in this new Constitution, but rather for the plurinational State to be transversal and recognize all the first nations and their self-determination in all areas: legal, political, social, cultural..."