She succeeded her brother Ubertino and also inherited her elder sister Mabilia's Italian possessions in Parma.
In 1278, the year of her succession, Isabella was requested by her new lord, Charles of Anjou, to do homage to his new bailli at Glarentsa.
When the barons of the Principality of Achaea, of which the ruler of Bodonitsa was chiefest of twelve peers, refused to do homage to the bailli Galeran d'Ivry as vicar general, the primary reason was the absenteeism of their primus inter pares, Isabella.
She died childless and left open a succession dispute, which was eventually solved by the arbitration of William I of Athens, then acting bailiff of Achaea, in favour of her cousin Albert.
According to an unfounded conjecture by Karl Hopf,[1] she was married to Anthony le Flamenc.