Isabelle is a town in Pierce County, Wisconsin, United States.

As of the census[2] of 2000, there were 315 people, 113 households, and 88 families residing in the town.

There were 118 housing units at an average density of 11.3 per square mile (4.4/km2).

15.9% of all households were made up of individuals, and 2.7% had someone living alone who was 65 years of age or older.

None of the families and 2.5% of the population were living below the poverty line, including no under eighteens and none of those over 64.