Her home, the Isabelle Bowen Henderson House and Gardens in Raleigh, North Carolina, is listed on the National Register of Historic Places.
[3] In 1936, Henderson opened an art studio in Raleigh and became known throughout Eastern North Carolina for her crayon portraits.
[5] Henderson's home in Raleigh became famous for her garden, which included a collection of iris and hemerocallis.
[1] She married Edgar H. Henderson in 1932 and moved to Williamstown, Massachusetts, where her husband served on the faculty at Williams College.
[1] Her father purchased a Victorian home on a 1.2-acre lot in the Oberlin Village neighborhood for Henderson and her husband to help them get back on their feet.
[4] Henderson added three outbuildings to her residence to create a quadrangle, including an herb house and a two-car garage.