Ischemic preconditioning

Ischemic preconditioning (IPC) is an experimental technique[1] for producing resistance to the loss of blood supply, and thus oxygen, to tissues of many types.

[4] In an experimental setting if the left anterior descending coronary artery of the animal is ligated the downstream cardiac cellular mass is infarcted and will be injured and then die.

Early preconditioning is thought to be stimulated by local action of adenosine, opiates, and bradykinin, which are all endogenously released by ischemic cells.

[citation needed] It has also been shown that the protective effect of IPC is suppressed by pathological conditions such as hypercholesterolemia, hyperglycemia, hypertension, cardiac hypertrophy, and hyperhomocysteinemia.

The one published study,[citation needed] an autopsy series from the Office of Chief Medical Examiner of the City of New York demonstrated significantly less evidence for coronary occlusive disease.