Isetemkheb D was the sister-wife of the Theban High Priest of Amun Pinedjem II during the Twenty-first Dynasty of Egypt.

Isetemkheb D was the daughter of the King's Son, Theban High Priest of Amun and General, Menkheperre, and his wife, Isetemkheb C. Isetemkheb D married her brother Pinedjem II.

[1] Isetemkheb and Pinedjem II are thought to have had four children:[1] [2] Isetemkheb's mummy and coffins were found in the royal cache found in TT320 in Deir el-Bahari in Thebes.

Istemkheb's mummy was never unwrapped.

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