Isetnofret (or Isis-nofret or Isitnofret) (Ancient Egyptian: "the beautiful Isis") was a royal woman of Ancient Egypt and, as the Great Royal Wife of Pharaoh Merenptah, she became Isetnofret II.

Another possibility is that Isetnofret II is a daughter of King Ramesses II and his second great royal wife, Queen Isetnofret I.

Her children include: The titles of Isetnofret II include: Lady of The Two Lands (nbt-t3wy), Great King’s Wife (hmt-niswt-wrt), Mistress of Upper and Lower Egypt (hnwt-Shm’w -mhw), King’s Wife (hmt-nisw).

If she was the daughter of Khaemwaset, she may have grown up in Memphis, otherwise, she grew up in Piramesse.

The tomb of a royal lady named Isetnofret was discovered in Saqqara during 2009 excavations by Waseda University.