Isfandyadh (Middle Persian: Spandiyār) was an Iranian aristocrat from the Ispahbudhan family, who was the ruler of the Sasanian province of Adurbadagan.
Isfandyadh first appears in 642/643, where he is mentioned as the prince of Adurbadagan, who at the head of a big army along with Muta and Varaztirots, fought the Muslim Arabs at Waj Rudh, a village in Hamadan.
Some years later, in 651, the Arabs invaded Adurbadagan, the domains of Isfandyadh and his brother Bahram.
According to Bal'ami, Isfandyadh is known to have said that: "If you [were to] kill me all of Adurbadagan [will] rise in avenging my blood, and will wage war against you.
However, Bahram, the brother of Isfandyadh, refused to submit to the Arab forces and kept resisting them.