Her next Tamil movie was En Swasa Kaatre (1998) opposite Arvind Swamy, directed by K. S. Ravi, with music by A. R. Rahman followed by a cameo appearance in Praveen Gandhi's Jodi starring Prashanth and Simran.

After a brief appearance in Bollywood's Fiza and Rahul, she came back to the south in 2001 for Sundar C's Tamil project Kaathal Solla Vanthen; the movie never took off.

[6] In 2000, Koppikar started her Bollywood career with a small role alongside Karisma Kapoor and Hrithik Roshan in Khalid Mohamed's Fiza and an item number appearance in Prakash Jha's Rahul.

[7] In 2002, Koppikar appeared in an item number in Ram Gopal Verma's underworld movie Company starring Ajay Devgan, Vivek Oberoi and Manisha Koirala.

And in Harry Baweja's Qayamat: City Under Threat, she played one of three terrorists fighting off co-stars Ajay Devgan and Sunil Shetty; a role which earned her a Filmfare nomination in the Best Villain category.

Inteqam, directed by Pankaj Parashar and co-starring Manoj Bajpai, saw her revive the role played by Sharon Stone in the original Hollywood version: Basic Instinct.

[12] Two more comedies saw her make guest appearances: David Dhawan's Salman Khan vehicle Maine Pyaar Kyun Kiya?, and Abbas–Mustan's whodunit, 36 China Town with Akshaye Khanna and Kareena Kapoor.

She also starred in Ram Gopal Varma's gangster flick D: Underworld Badhshah alongside Randeep Hooda and Chunky Pandey.

[13] In 2006 Farhan Akhtar directed a remake of the Amitabh Bachchan hit Don: The Chase Begins Again with Shahrukh Khan in the lead.

Vicky Ranawat's Haseena Smart Sexy and Dangerous managed a release towards the end of 2006, but Jagdish A Sharma's murder mystery Gahraee[14] appeared directly on DVD while Hansal Mehta's Raakh and Jahnu Barua's Har Pal were shelved.

Koppikar's high-profile film of 2007, Nikhil Advani's Salaam-e-Ishq, had her sharing limited screen time with Sohail Khan.

Koppikar's first film release of 2008 was Atul Agnihotri's Hello, based on the best-selling novel One Night @ the Call Center by Chetan Bhagat.

[20] She made her digital debut with the ALTBalaji web series titled Fixerr (2019) where she plays the role of sub-inspector Jayanti Javdekar, who lives in a modest house with her young son and husband.

In addition to this she has appeared in two music videos: Patli Kamar by KK for a private album commissioned by Sony in 2001/2002; and Bandish Projekt's Bhor (Satyam Shivam Sundaram) in 2004, choreographed by Bosco-Caesar.

She served as a judge in the Miss Universe 2008 contest, held on 14 July in Vietnam alongside, amongst others, fashion designer Roberto Cavalli and former winner in 2004 Jennifer Hawkins.