[1] He was advised by Chief Rabbi of the United Kingdom Joseph Hertz to obtain an academic education.

[10] He studied at the University of London, earning a First Class BA Honours degree in Semitic languages, followed by two doctorates: the PhD and the DLit.

[11][1] He served as rabbi of Middlesbrough Hebrew Congregation from 1920 to 1928,[12] and then joined the teaching staff of Jews' College, London.

[6] Epstein is known for editing the first complete English translation of the Babylonian Talmud, which published by the Soncino Press between 1935 and 1952.

[1] He recruited many scholars for the project, personally reviewing all of the work as it was produced and coordinating notations and commentary on the text.