[1] Isingiro is approximately 42 kilometres (26 mi) southeast of Mbarara, the largest city in the Ankole sub-region.

The town of Isingiro is surrounded by the villages of Nyakigera, Gayaza, Rwembwa, Mabona, Kibwera, and Rumira.

[2] Isingiro is located approximately 310 kilometres (193 mi), by road, southwest of Kampala, the capital and largest city of Uganda.

UBOS calculated that the population of Isingiro Town Council expanded at an average annual rate of 3.6 percent between 2015 and 2020.

[6][7]The following additional points of interest lie within or close to the town:[4] (a) the headquarters of Isingiro District administration (b) the offices of Isingiro Town Council (c) Isingiro central market, the source of daily fresh produce and (d) the 74 kilometres (46 mi) Mbarara–Kikagati Road passes through the western neighborhoods of the town in a general north to south direction.