[2] Pierre is a French form of the name Peter, derived from the Greek Πέτρος, Petros, meaning "rock" or "stone".

The early French-speaking fur traders ascribed the name, which means "rock island", to similar locations.

[2] The westward advance of the Grand Trunk Pacific Railway (GTP) rail head passed through Isle Pierre in early March 1914.

[7][8] On April 6, 1914, officials drove in the golden spike, completing the GTP transcontinental line (later part of the Canadian National Railway (CN)).

[10] In 1954, when the Department of Public Works blasted a beaver dam, a torrent washed out the track 5 kilometres (3 mi) east of Isle Pierre.

[11] When a locomotive and two baggage cars of a passenger train plunged into a deep hole, a CN fireman was fatally crushed and burned.

[12] In July 1983, the eastward advance from Prince Rupert of a team upgrading the track to handle heavier locomotives reached Isle Pierre.

[27][28] In 1926, the farmers' institute opened a 10-by-6-metre (32 by 20 ft) community hall,[29] which became the venue for social events and dances.

[35] Joseph Robert Boyd opened a wood frame store about 1.7 kilometres (1.1 mi) southwest of the western ferry dock.

Wilfred John Aizlewood was the final postmaster 1939–1956,[32] operating a store for the greater part of that time.

[49] The junior section of this annual Northern Hardware canoe race, covering Miworth–Prince George, commenced in 1971.

[52] The annual event was revived in 2015 as an Isle Pierre–Prince George race,[49] with the junior section (Simon Fraser Class) starting from Miworth.

[62] In February 1931, when a yoke broke between a team hauling down the hill, the out-of-control tie-laden sleigh forced the horses off the end of the ferry into the water.

[70] In October 1952, when the diversion tunnel at the upstream Kenney Dam was closed, the water level at the ferry dropped 1 metre (3 ft) within 72 hours.

[71] In 1963, the nearby road was washed out, becoming unsuitable for tourist traffic bypassing Highway 16 and taking the scenic route.

[76] For sawmill workers living on the eastern side, closures meant a 80-kilometre (50 mi) trip via Prince George rather than a few kilometres drive.

[86] Lloyd Bros. Lumber operated more significant sawmills at Swede Creek, then Cluculz Lake, and then Isle Pierre.

[95] In 1976, $1.1 million of modifications were made for the mill to process smaller diameter wood and increase production.

[103] 1960: When an Aeronca Champion seaplane crashed nearby, the two occupants sustained only minor cuts and bruises, but the plane was destroyed.

[106] 1969: A man who shot a fellow section hand, with whom he shared a cabin and had a strained relationship, was found guilty of manslaughter.

[107][108] An operator at the Lloyd Bros. sawmill was fatally electrocuted when his forklift touched a 14,000-volt high tension wire.

[110] 2003: A lumber truck driver, who fell from the top of his load, died while dangling upside down in a harness.