In 1913, it was acquired, together with a nine-acre estate, by film producer George Berthold Samuelson.
Filming of Conan Doyle's A Study in Scarlet began in summer 1914, and the studios were officially opened on 1 July.
However, in 1928, an expensive lawsuit with the American actress Betty Blythe forced Samuelson to sell Worton Hall to British Screen Productions.
Films produced here include Invader (1936) with Buster Keaton; Under Secret Orders (1937) otherwise called Mademoiselle Docteur, with Erich von Stroheim; The Small Back Room (1949); State Secret (1950) with Douglas Fairbanks Jnr.
Whilst being used as Isleworth Studios, the original Odeon sign was visible up until the early 1990s.
The studios finally ceased operations at the building in 2001 and the auditorium section was taken down the following year.