Isocarpha megacephala is a New World species of plants in the family Asteraceae.

It has been found only in northeastern Brazil (Bahia, Pernambuco, Paraíba).

[1] Isocarpha megacephala is an annual or perennial herb up to 50 cm (19.5 in) tall.

Leaves are up to 7 cm (3 in) long.

One plant produces several flower heads, each 8–10 mm (0.31–0.39 in) across (thus larger than the other species) each head on a long flower stalk, each head with 200-300 white disc flowers but no ray flowers.