For some time he resided at the court of the Mongol Ilkhan, Ghazan, in Persia, rising to become his ambassador or liaison[1] to the Kingdom of Cyprus.
[3] In a letter dated 20 September 1300 from Pope Boniface to the Archbishop of Nicosia, Isol was titled "Vicar of Syria and the Holy Land for Ghazan the Emperor of the Tartars",[4] suggesting that he was put in charge of coordinating relations between the Crusader states and the Mongols.
[5][6] Isol is also a probable source for some of the information about Europe in the "History of the World" chronicle by the Mongol historian Rashid-al-Din Hamadani.
[7] In 1300, Isol acted as an intermediary between Ghazan and European leaders such as Henry II of Cyprus and Pope Boniface VIII.
[8] Isol was also present as the Mongol representative in July 1300 aboard a small Cypriot fleet of sixteen galleys which were attacking Rosetta and other targets along the Palestinian coast.