Isola Maggiore is the second largest island (at approximately 24 hectares (59 acres)) on Lake Trasimeno, in Umbria, central Italy.

It is a frazione of the comune of Tuoro sul Trasimeno, and is the only inhabited island on the lake, with a current population of 35.

St Francis of Assisi lived 40 days on this island as a hermit during Lent (probably 1211 although the date is unsure).

After the Fascist authorities left Perugia and the British arrived at Sant'Arcangelo on 19 June the prisoners were eventually rowed to safety by the island's fishermen, to whom a monument has been erected in the open space next to the Lace Museum.

[citation needed] Today the town is dependent on fishing, agriculture, tourism and traditional Irish lace making which was introduced in the 1900s.