"Nobody Praying for Me" was sent to US Active Rock stations on 28 April 2015 as the third single off of the album.

[1] "Save Today" was sent to US Active Rock stations on 22 September 2015 as the fourth single off of the album.

[2] Loudwire wrote "the group offers one of their finest albums to date by digging deep and expressing themselves in a variety of ways".

[15] AllMusic said "Seether gravitate toward the melodic, a shift apparent in both the verses and the riffs, although there's still a tendency to grind out thick neo-grunge guitar workouts both slow ("My Disaster") and fast ("Suffer It All")".

[16] Blabbermouth.net wrote "Isolate and Medicate shows Seether trying to roll after more than a decade and a half in the life, but it presents a case of identity crisis, since it's apparent these guys are capable of writing pretty kickass stuff if left to their own devices.