The album's lead single "Remedy" held the top spot on the Billboard Mainstream Rock Tracks chart for a total of eight weeks.

In a 2022 interview with American Songwriter, Morgan explained the song's origin: "I was in Los Angeles, and I would go to the producer’s house every day, and he had a studio in his garage.

[...] [W]hen 'Remedy' was chosen, there was a big fight, because the label didn't want us representing the heavier side of the band, so I was really happy we won that victory.

He further commented that, for the song's music video, director Dean Karr was the first to propose casting mixed martial artist Tito Ortiz in the role of Uncle Sam.

"[13] It was allegedly nearly shelved after Callahan repeatedly objected to the song each time Morgan showed it to the band prior to recording for the album.

All lyrics are written by Shaun Morgan; all music is composed by SeetherSeether Other personnel Before the release of Karma and Effect, a blog post from the band on their website stated that there would be three B-side tracks for the album: "Let Me Go", "Innocence" and "Blister".

"Innocence" and "Blister" were never mixed or mastered but both songs, likely obtained off the album's demo tapes, were made available on a fan site for a short time.