Isomigrastatin is an analogue of migrastatin, an organic compound that naturally occurs in the Streptomyces platensis bacteria.

Isomigrastatin has shown promise as a drug in the treatment of cancer.

[2] Through LACDAC reaction, Luche reduction, aqueous Ferrier rearrangement and Epoxidation, reagent 6, 7, 8, 9, 10 are synthesized to 11.

Aldehyde 12 reacts is alkyldenated by Witting reagent 13 to make 14, and 14 is hydrogenated to afford 15.

Using lithium borohydride, lactol arrangement of reagent 11 is reduced to create alcohol 16 which could be converted to 17 as well.