[2] Digitalis isabelliana is a broadleaf evergreen perennial shrub, growing up to 1.5 m (4 ft 11 in) in height, with a much-branched woody base.

The leaves are broadly ovate, dark green, glabrous, and with a serrated margin.

[4][5] Digitalis isabelliana grows primarily in the subtropical biome of the Canary Islands, where it is endemic to Gran Canaria, where it occurs on the moister northeast and centre of the island, favouring the undergrowth beneath stands of Canary Islands pine.

[4][6] In the wild it favours damp and wooded areas.

[7] D. isabelliana is considered an endangered species due to diminishing habitat, with few large colonies.