[1] Unfortunately, due to the Wall Street crash of 1929 that caused the Great Depression in the United States, there was not much of a market for such a car.

Count Lodovico Mazzotti, who took over after Isotta and Fraschini left the firm in 1922, had been negotiating a manufacturing deal in 1930–1931 with Henry Ford that could have saved the company's car production; however, Benito Mussolini's National Fascist Party were in control of Italy's commerce and industry and, intent on keeping Isotta Fraschini focused on building aircraft engines for Italy's military and opposing foreign investment, prohibited all further talks with the Americans.

Engineer Giustino Cattaneo, Isotta Fraschini's technical director since 1905 and the driving force behind the company becoming a world-class car manufacturer, resigned in 1933.

It would be 13 years before the firm would attempt to put another car, the more modern Isotta Fraschini Tipo 8C Monterosa, into production.

8B owners included the Aga Khan III, William Randolph Hearst, Rudolph Valentino, Gabriele d'Annunzio and Pope Pius XI.