It is known from the southern Cordillera de Talamanca in Costa Rica, Cerro Pando in Costa Rica and Panama, and the Pacific slope in southwestern Panama.

The ventrum is white and has some scattered black blotches or smaller spots.

The groin and the thighs are bright white and have scattered black spots.

[4][2] Isthmohyla calypsa live in primary humid lower montane forests along torrential streams[1] at elevations of 1,500–2,100 m (4,900–6,900 ft) above sea level.

Also habitat loss from smallholder livestock farming is a threat for this species.