Isurus desori or "Desori shark", or "Desori mako shark" is an extinct species of Mako shark, that lived in Oligocene and Middle Miocene, between 34 and 11 million years ago.

The Isurus desori hunted squids, fish and marine mammals.

The fossil of I. desori was discovery in Chesapeake Bay region.

It is believed to be related to C. hastalis, and C. xiphodon, as well as the Mako shark (Isurus oxyrinchus).

[3] Scientists believe that I. desori belongs to the subfamily Isuridae, where it evolved into the only two contemporary species, I. paucus and I. oxyrinchus, the only surviving species of the genus Isurus.