[3][5] In her time as a reporter and presenter, she covered various events including the Aceh tsunami, the 2005 Bali bombings, and the 2008 United States presidential election.

[3] Past interviewees include U.S. President George W. Bush, Secretary of State Hillary Clinton, and sports figures Pep Guardiola, Cesc Fàbregas, Robert Pires, and Javier Zanetti.

[6] In 2014, Isyana joined other young people, including Grace Natalie and Raja Juli Antoni, to found the Indonesian Solidarity Party (PSI).

[7][8][9] The following year, she formally ended her journalism career and began pursuing politics as a chair of the PSI's Central Leadership Council.

[13] In October 2024, Isyana was named deputy minister of population and family development in Joko Widodo's Red White Cabinet.