The Itapanhapima Sustainable Development Reserve (Portuguese: Reserva de Desenvolvimento Sustentável de Itapanhapima) is a sustainable development reserve in the state of São Paulo, Brazil.

The reserve is in the Cananéia lagoon estuary, an important nursery for fish and aquatic mammals.

It contains large mangrove swamps managed by the traditional populations of the reserve and used by some families for extraction of the native oyster and uçá crab.

[3] The Itapanhapima Sustainable Development Reserve was created by state law 12.810 of 21 February 2008.

[5] It is administered by the state forest foundation (Fundação para Conservação e a Produção Florestal do Estado de São Paulo).