The district lies in the south-western portion of the Singida Region with 279,069 people and encompasses a large area mostly made up of protected game reserves.

[7] In the district the Rungwa Game Reserve with the other Kizigo and Muhesi game reserves make up the Rungwa-Kizigo-Muhesi ecosystem and covers an area of 17,340 square kilometres (6,700 sq mi) in Itigi and neighboring districts.

[6][3]: 5 Wards (2016 Population)[12]: 103 In 2016 the Tanzania National Bureau of Statistics report there were 123,515 people in the district, from 112,565 in 2012.

People of the district are of the tribes of Wagogo, Waturu, Wanyaturu, Wasukuma, Wanyamwezi, and Wakimbu.

[12]: 103 [6][13]: 47 Agriculture and livestock raising are the primary economic activities, along with trade, beekeeping and gypsum mining.