Iva Susan Greenwald is an American biologist who is Professor of Cell and Molecular Biology at Columbia University.
She is particularly interested in LIN-12/Notch proteins, which are the receptor of one of the major signalling systems that determine the fate of cells.
[2] She moved to the MRC Laboratory of Molecular Biology in 1983[1] where she worked alongside Jonathan Hodgkin, Gary Ruvkun and Victor Ambros, who encouraged her to try to clone LIN-12.
[1] It took her two years to develop a strategy to clone LIN-12 (Tc1 transposon tagging), and she identified that that genetic sequence contained epidermal growth factor (EGF) motifs.
Amongst these processes, Greenwald studies the role of LIN-12/Notich in binary regulation, feedback mechanisms and signal transduction.