He began his leadership through Indian Catholic Youth Movement (ICYM) organization from Mudarangady parish.
In 2008, D'Souza was named as the candidate of Indian National Congress for Mangalore South constituency.
D'Souza was a front runner to contest again from Mangalore South constituency in 2013 Karnataka State Elections.
He is currently the KPCC Member and Convener of Election Committee for the Indian National Congress in Dakshina Kannada.
[7][8] D'Souza led the protests against the injustice and subsequent inaction by the state government and also when some women were attacked in a reported moral policing incident.