He was the CEO of Diageo, a FTSE 100 British multinational alcoholic beverages company, from 2013 until his death in 2023, succeeding Paul S.

[2][3] His mother, Nina, was a French language and music teacher, while his father, Manuel, was the chairman of the Indian Railway Board.

He went on to complete his bachelors in economics and mathematics from St. Stephen's College, Delhi, and followed it with a post-graduate degree from the Indian Institute of Management Ahmedabad.

[11] During this time, he led the company to sell most of its wines business and its low-margin mass-market beers and shift its focus toward premium brands like Guinness and spirits like Johnnie Walker.

[14][8] Menezes was a non-executive director of the US-based fashion retailer Coach, Inc. and the chair of the Scotch Whisky Association.