Yizhakevych was born in the village of Vyshnopil, Kiev Governorate.
[1] Yizhakevych's paintings reflect themes from Ukrainian history, such as Kyi, Shchek and Khoryv, Cossack battles, and Haidamaky.
Yizhakevych also illustrated works by Ukrainian writers, among them: Taras Shevchenko, Lesya Ukrainka, Ivan Kotliarevsky, Ivan Franko, and produced paintings of common people and their lives.
Yizhakevych made numerous artistic contributions to Kyiv churches.
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