Ivane I Zakarian (Armenian: Իվանե Ա Զաքարյան; Georgian: ივანე I მხარგრძელი, romanized: ivane I mkhargrdzeli) was an Armenian prince, and a Court official of the Kingdom of Georgia holding the offices of Msakhurtukhutsesi (Majordomo) and Atabeg (Governor General) for Queen Tamar of Georgia during the early 13th centuries.

The brothers, Zakare and Ivane Zakarian, who were sons of Sargis, were the most successful representatives of the family, who were military commanders under Queen Tamar.

[13][14] The brothers commanded the Armenian-Georgian armies for almost three decades, achieving major victories at Shamkor in 1195 and Basen in 1203 and leading raids into northern Iran in 1210 and suppression of rebellions of mountaineers in 1212.

[9] The beautiful murals of Akhtala Monastery, commissioned by Ivane in 1205–1216, are an example of Armenian-Chalcedonian art, blending Byzantine, Armenian and Georgian styles.

[21] The Zakarids served under the Georgian king George IV of Georgia to repulse them, with Ivane acting as atabeg (Governor General) and Amirspasalar (Commander-in-chief), their army only half the size of the Mongol one.

[21] A third encounter the same year virtually annihilated the Georgian army, and the Mongols continued north to confront the Kipchaks at far as Soldaia, and the Rus' Principalities at the Battle of the Kalka River.

[23] Before dying, George IV made an alliance with the Sultanate of Rum, by marrying his sister Rusudan to Ghias ad-Din, son of the emir of Erzurum.

[23] In 1222, the Kipchaks, fleeing from Mongol devastation, came to the Armenian city of Gandzak, where they encountered the troops of the atabeg Ivane Zakarian, who were again defeated.

[15] When the Khwarazmians under Jalal al-Din Mangburni invaded the region in 1226–1230, Dvin was ruled by the aging Ivane, who had given Ani to his nephew Shahnshah, son of Zakare.

This defeat led to royal court of Georgian Queen Rusudan (1223–1245) moving north to Kutaisi, which exposed the south of the country to subsequent looting during the Mongol invasions of Georgia.