The domain was centered at Iwamurada Jin’ya, located in what is now part of the city of Saku in Nagano Prefecture.
This marked the start of Iwamurada Domain, which his descendants continued to rule uninterrupted until the Meiji restoration.
The 6th daimyō, Naito Masatsuna, was a brother of Mizuno Tadakuni and served as a rōjū in the administration of the Tokugawa shogunate.
Under the new Meiji government, Naitō Masanobu, the last daimyō of Iwamurada Domain was given the kazoku peerage title of shishaku (viscount).
As with most domains in the han system, Iwamurada Domain consisted of several discontinuous territories calculated to provide the assigned kokudaka, based on periodic cadastral surveys and projected agricultural yields.