She has been widely known for her work as a VJ in the music channel Myx and as the Chika Minute segment anchor in GMA's primetime newscast 24 Oras.
She used to be a member of a touring band in Australia called Iron & Clay that address issues in schools and churches such bullying, drunk driving, and self-esteem.
After she gained a "cult" following, the management team of GMA Network took notice and cast her in the daytime drama Walang Hanggan.
Villania's feature film debut was in the 2004 drama "A Beautiful Life" alongside acclaimed actresses Gloria Romero, Dina Bonnevie and Amy Austria.
In the same year, Villania appeared in the critically acclaimed historical film Aishite Imasu 1941: Mahal Kita.
After signing an executive contract with GMA Network in October 2014, Villania made a part of Sunday All Stars (2013–2015), a variety show.
[20] Initially having doubts about the Tagalog language, she prepared for her role by reading tabloids to learn more Filipino words.