Sarah Hilomen-Velasco, Cyril Chaves, and Efren Mamac currently serve as anchors.

One Mindanao was also re-aired for national viewers under GTV’s late-night block "Regional TV Strip" every week.

Its main newscaster is Tek Ocampo; he started with Testigo (first named Testigo: GMA Super Balita) on October 4, 1999, and made a name as a national reporter for GMA News when he left the show in 2002.

[6] At the same time, GMA Cagayan de Oro reopened its studios with former relief anchor and correspondent Clyde Macascas (later replaced by Cyril Chaves, Ethel Ipanag and James Paolo Yap), which is used by the newscast.

Before the launch of its studio, reports and headlines from Cagayan de Oro and the rest of Northern Mindanao and Caraga are aired live from the GMA Cagayan de Oro Control Room.

From Soccsksargen, BARMM, and Zamboanga Peninsula (including Zamboanga City), the newscast brings reports and headlines, the only one used Cebuano and Filipino for the Mindanaoan newscast from August 28, 2017 to November 22, 2019, now switched to full Cebuano language on November 25, 2019.

One Mindanao was relaunched on August 19, 2019, adopting graphics and studio sets for Davao and Cagayan de Oro stations from the national newscast.

Co-anchors and correspondents Jandi Esteban, Cyril Chaves, and Rgil Relator joined Hilomen-Velasco in the anchor team on September 20, 2021, all taking turns anchoring the newscast, using the two-anchor format that the other regional newscasts adopted.

Three days later, on September 2, 2024, the newscast tweaked a major revision of its title card.