Izumisano (Japanese: 泉佐野市, Izumisano-shi, [izɨᵝmʲisano ɕi]) is a city located in Osaka Prefecture, Japan.

The northern third of Kansai International Airport is located within the city limits on an artificial island offshore, and the area within Izumisano includes the connecting bridge to the mainland.

After the Meiji restoration, the village of Sano established within Hine District with the creation of the modern municipalities system on April 1, 1889.

Izumisano has a mayor-council form of government with a directly elected mayor and a unicameral city council of 18 members.

Izumisano collectively with the cities of Kaizuka, Sennan, and the smaller municipalities of Sen'nan District contributes two members to the Osaka Prefectural Assembly.

In terms of national politics, the city is part of Osaka 19th district of the lower house of the Diet of Japan.