[1] He was the main organizer of a popular anti-vaccination demonstration that took place on 23 March 1885 outside Leicester Temperance Hall in which the whole practice of vaccination was condemned.

[3] He argued that people in Leicester had lower rates of smallpox than Glasgow because of improved sanitation, a river passing through the town and its inhabitants were encouraged to go outside and get as much fresh air as possible.

[2][4] Biggs testified to the Royal Commission that an anti-vaccination prisoner had been thrown into a "black hole" and made to suffer "every possible degradation".

[2] To the disappointment of Biggs the 1896 Report of the Commission supported the continuation of compulsory vaccination as protective against smallpox.

[2] John Douglas Swales has described Biggs' book Sanitation Versus Vaccination as an "exhaustive 785 page volume of misplaced evangelical zeal".