JAMA Network Open is a monthly open access medical journal published by the American Medical Association covering all aspects of the biomedical sciences.

It was established in 2018 and the founding editor-in-chief was Fred Rivara (University of Washington); since 2024, the Eli Perencevich (University of Iowa) has been editor-in-chief.

[1] The journal is funded by article processing charges and most articles are available under a Creative Commons license.

Article titles and abstracts are translated into Spanish and Chinese.

Additionally, it ranks 5th among purely open access journals in that subject category.