Isonami was laid down at Mitsubishi Heavy Industries Kobe Shipyard on 14 December 1956 and launched on 30 September 1957.

During the special repair work from 1962 to 1963, the equipment was modernized, and the unequipped radio wave detector (ESM) NORL-1 was put in the back.

On December 24, 1964, she left Yokosuka for a trial run, and the bow of the Liberia-registered tanker Olympic Grace (37,000 tons) collided with the rear port side due to heavy fog and was damaged.

She was removed from the register on July 1, 1987, along with her sister ship JDS Shikinami.

In 1988, she was prepared as a target ship at the Etajima Shipyard, and was sunk by anti-ship guided bullets.