He also had a supporting role in the 2013 film American Hustle, portrayed the eponymous Ben-Hur in the 2016 historical drama, and appeared as one of the main characters in the fourth season of the FX anthology series Fargo (2020).

On his father's side, he has Italian, Irish, Scottish, Scotch-Irish, Welsh, and English ancestry, and is a great-grandson of Canadian actor Walter Huston.

[5] Through his maternal grandfather's father, The 5th Marquess of Cholmondeley, Huston is descended from Sir Robert Walpole, the first Prime Minister of the Kingdom of Great Britain.

In 2012, he played the part of narrator on avant-garde musician John Zorn's album A Vision in Blakelight, an homage to William Blake.

[14] In 2020, he had a supporting role in the fourth season of the FX black comedy crime drama Fargo as Odis Weff, a corrupt Kansas City police detective with severe OCD.

In 2023, Huston made his directorial debut with Day of the Fight, starring Michael Pitt as a once renowned boxer who has since fallen on hard times.