Tsai graduated from National Taiwan University with a Bachelor of Laws (LL.B.)

She promoted e-commerce related laws and industrial development, issuing draft Regulations on the Management of Electronic Payment Institutions that were adopted on May 3.

She was a founder of Lee, Tsai and Partners (1998 – 2013), General Counsel of IBM Greater China Group (1996 - 1998), General Counsel of IBM Taiwan (1991 - 1996), Judge of Taipei, Shih-Lin, Taoyuan and Chang hua District Courts (1982 - 1991).

Tsai inaugurated the "Tibetan Cultural and Artistic Festival Activities" in May 2015 that elevated three running themes, including thangka painting exhibitions, public Buddhist prayer, Sanskrit music performances to showcase Tibetan culture and Taiwanese religious festivals.

Tsai and her husband possess assets worth NT$ 100 million in Mainland China.