Jacob Margolioth of Nuremberg (Hebrew: רבי יעקב בן משה מרגליות-יפה; January 1430 – 1492) was a 15th-century German rabbi and halakhic authority.
In his early years, his family moved to Nuremberg, Germany, where Jacob studied.
His contemporaries Joseph Colon and Judah Minz speak of him as one of the greatest rabbis of his time.
In one case, a quarrel between Moses Capsali and Joseph Colon, Jacob sided with the former.
In his later life, he authored a halakhic work known as "Seder Giṭṭin wa-Ḥaliẓah".