In November 2013, it was revealed that a musical version of the album Jagged Little Pill by Alanis Morissette was being adapted for the stage[3] with composer Tom Kitt attached to pen new arrangements and orchestrations for the production.

[17] In addition to music from the show's namesake album, the musical also features other songs from Morissette's catalog, including "Thank U", "That I Would Be Good", and "So Pure" from 1998's Supposed Former Infatuation Junkie, "So Unsexy" and "Hands Clean" from 2002's Under Rug Swept, "Unprodigal Daughter" from 2002's Feast on Scraps, "No" from the Japanese edition of 2012's Havoc and Bright Lights, and "Uninvited" from the soundtrack of the 1998 film City of Angels.

Morissette also wrote two new songs for the musical, "Smiling" and "Predator", with the former included as the second single on her ninth studio album, Such Pretty Forks in the Road.

She writes about her husband Steve's job promotion, her daughter Frankie's art, and her son Nick's early admission to Harvard University.

On the last day of Frankie's English class before winter break, she reads a short story she wrote aloud.

Frankie and Phoenix find each other and leave the crowded party to talk alone, and they discuss their imperfect family lives.

The following day, Jo shows Frankie pictures that are circulating throughout the school of Bella, Nick's friend, who was drunk, passed out, and had her shirt pulled up at the party.

MJ walks to the church for the first time in a while to pray about her failing marriage, struggling relationship with Frankie, and for help with her addiction.

Jo, enraged that the one person they felt understood them doesn't love them, ends the relationship ("You Oughta Know").

[21] In March 2018, principal casting was announced, which included Elizabeth Stanley starring as Mary Jane, Sean Allan Krill as Steve, and Derek Klena as Nick.

[22] Additionally, Lauren Patten was cast as Jo, Celia Rose Gooding as Frankie, and Kathryn Gallagher as Bella.

[25] The principal cast from the world premiere production all transferred with the show to Broadway, with Paulus also continuing as director.

[26] The show began previews at the Broadhurst Theatre on November 3, ahead of an official opening night on December 5, 2019.

[31] The producers cited the need to "prioritize the health and safety of the cast, crew, and entire team", retroactively making December 17, 2021 its final show after 36 previews and 171 performances.

The cast features Natalie Bassingthwaighte (Mary Jane), Tim Draxl (Steve), Emily Nkomo (Frankie), Liam Head (Nick), Maggie McKenna (Jo), Grace Miell (Bella) and Aydan (Phoenix).

It stars Heidi Blickenstaff as Mary Jane, Chris Hoch as Steve, Lauren Chanel as Frankie, Dillon Klena as Nick, Jade McLeod as Jo, Allison Sheppard as Bella, and Rishi Golani as Phoenix.

[36] Following technical rehearsals that began in August 2022 in Louisville, Kentucky, the North American tour opened on September 6, 2022, at the Smith Center in Las Vegas.

The North American tour of Jagged Little Pill officially closed on April 7, 2024 in Worcester, MA after 474 performances.

Jagged Little Pill features songs previously written and recorded by Alanis, with the exception of "Smiling" and "Predator", which she wrote for the show.

[48] In the fall of 2022, Atlantic records released one new, stand-alone track featuring Heidi Blickenstaff and the original Broadway cast singing Uninvited.

A young adult novel adaptation was announced in Rolling Stone on December 9, 2021,[49] and was released on April 26, 2022, by Abrams Books,[50] written by Eric Smith in collaboration with the show's creators.

In the original world premiere production at the American Repertory Theater, the character of Jo was nonbinary, and portrayed by Lauren Patten, a cisgender woman.

During the original production, Patten confirmed the use of they/them pronouns for the character and referred to them as nonbinary and genderqueer on multiple occasions.

[51] Despite this, following her Tony Award win for Best Featured Actress in a Musical, Patten thanked her "trans and nonbinary friends".

[53] On September 18, 2021, lead producers Vivek Tiwary, Arvind Ethan David and Eva Price apologized for changing Jo's gender identity and for not listening to feedback.

[54] In their statement, the producers acknowledged their mistakes as they "set out to portray a character on a gender expansive journey without a known outcome".

[54] The show hired a new dramaturge to revise the scripts, and pledged to cast actors to play Jo who are on their own gender journeys.

[55] Canadian actor Jade McLeod, who identifies as nonbinary, was cast as Jo in the North American tour of Jagged Little Pill.

Always engaging, often moving and even rousing, the show boasts dramatic interest and integrity on its own theatrical terms, courtesy of director Diane Paulus, first-time librettist Diablo Cody, and that peerless, soulful balladeer of the modern Western condition, Alanis Morissette.

[62] Rolling Stone awarded the production four out of five stars, writing that although the show feels "overly 'woke'" at times and "wears its earnestness on its sleeve", Jagged Little Pill burns with passion ... and enthusiastic beauty.