[7] Marrufo was selected to officiate in the 2018 FIFA World Cup, and his first appointment was the Group G match between Belgium and Tunisia.

Marrufo refereed the 2018 FIFA Club World Cup final between Real Madrid and Al Ain.

He refereed the second leg of the 2019 CONCACAF Champions League final between Monterrey and Tigres on May 1, 2019.

[8] On May 17, 2019, Marrufo was appointed to be a referee for the 2019 CONCACAF Gold Cup in the United States.

He is the husband of teacher and UTEP graduate Zinnia Mares Marrufo and they have two children together.