In the early 1990s, when he was 17 years old Artikkhodjaev opened his first company, Jahongir LLC; a hairdressers and a shoe shop.

In 1994, Artikkhodjaev opened his first car service centre, and began selling aluminium profiles, the latter of which became a cornerstone of his subsequent business development.

President Shavkat Mirziyoyev nominated him to the role, stating that Artikkhodjaev's success as an entrepreneur made him the most suitable candidate for the job.

[9] He stated “I give my word that I will work to eradicate cases of corruption, I will serve fairly, every day, every hour, every minute I will pay attention to ensuring that people live in prosperity and contentment, to solve their socio-political problems.” Since Artikkhodjaev took up his position, according to the State Statistics Committee, the GDP of Tashkent increased from 15.3 trillion soums in 2019 to 23.7 trillion soums in 2021.

[10] On January 30, 2023, Jakhongir Artikkhodjaev was excluded from the number of senators of the Senate of the Oliy Majlis of the Republic of Uzbekistan[11] Since 2020, the Khokimyat has organised a Youth Forum in Tashkent to engage with young people and to invigorate the active role of young people in their community.

[13] The 2021 edition included sessions on women's rights [14] and environmental issues.In September 2021, Artikkhodjaev announced that the Khokimyat was introducing a special scholarship for five school students and their teachers.

It is reported that the salary arrears to the players and staff of the club have been repaid at the expense of 22 billion soums allocated by sponsors.

[25] In 2021, the Government announced a plan to increase the area of retail space in Tashkent by 10 times, move heavy industry enterprises out of the city.

[28] In response to the COVID-19 pandemic in Uzbekistan, the Tashkent Khokimyat initiated the construction of an emergency distribution centre with over 500 beds, designed to receive patients with COVID-19.

This includes the renewal of the Capital's roads and canals,[31] bridges,[32] development of parks and recreational areas, as well as social housing.

[35] The khokimyat is carrying out a series of consultations with businesses and key stakeholders, that will feed into a forward-looking strategy on to make Tashkent a more attractive tourist destination.

The aim of the visit was to share Tashkent's experience in order to help develop Nukus as a modern city.

According to this recording, which was subsequently found to be doctored, Artikkhodjaev threatened journalists with sudden "disappearance" in case of refusal to cooperate.

“On November 16, 2019, an unknown person, in order to discredit the Khokim Jahongir Artikkhodjaev, distributed on social networks a recording lasting one and a half minutes (the meeting lasted two hours), edited from inappropriate words.”[38] Kun.Uz later published a correction in its article, admitting that the original recording was heavily edited and not representative of the conversation.

The development is in the heart of the city, and includes the construction of over 80 hectares of park, hotels, business district and shopping malls.