Born in New Orleans, Louisiana, Comiskey was in the United States Army during World War II, from 1944 to 1946.

He received a Bachelor of Arts degree from Loyola University New Orleans in 1949 and a Juris Doctor from Loyola University New Orleans College of Law in 1951.

[1] On January 16, 1967, Comiskey was nominated by President Lyndon B. Johnson to a new seat on the United States District Court for the Eastern District of Louisiana created by 80 Stat.

Comiskey served in that capacity until his resignation on June 15, 1975.

[1] Comiskey was thereafter in private practice in New Orleans until his death in that city on February 1, 2005.