Chase matriculated at Christ Church, Oxford on 15 December 1665, aged 15.
[2] In 1684, he acquired his estate in Little Marlow and built Westhorpe House there during Queen Anne's reign.
[3] Chase was a Freeman of the Apothecaries’ Company and was its Master from June 1688 to September 1689.
His father's patent granted the reversion of the office to Chase himself, and after his father's death in 1690, Chase became court apothecary to William III in June 1690, at an annual salary of £115, with an annual allowance of £127 and lodgings in Whitehall.
[2] At the 1690 English general election Chase was returned as Member of Parliament for Great Marlow in Buckinghamshire.