James E. Lyons, Sr. (born c. 1943) is an American academic administrator who has served as president of several historically black colleges and universities.

From 1973 to 1974, Lyons was an administrative assistant to the vice president for academic affairs, director of institutional research, and associate professor of education at Kentucky State University.

From 1978 to 1983, he served as vice president and dean of academic affairs, chief negotiator, and professor of education at Delaware State University.

From 1999 to 2007, Lyons served as president of California State University, Dominguez Hills, where he expanded academic programs and was involved with the installation of the $150 million Home Depot sports complex.

[3] In 2017, Lyons became chief transition officer of Concordia College Alabama appointed to serve as interim president for 6 months.