James Frederick Holland (May 16, 1925 – March 22, 2018) was an American physician and Distinguished Professor of Neoplastic Diseases at the Icahn School of Medicine at Mount Sinai in New York.

Though Holland was initially hoping that another slot would open up at Presbyterian, he found that he preferred to remain at a specialty cancer institution.

[6] In 1953, while Holland was a researcher at the National Cancer Institute (NCI), he designed a clinical trial for the treatment of acute leukemia.

When the NCI's new chief of oncology, Gordon Zubrod, agreed to continue the trial, it became the first multicenter study of acute leukemia.

[8] Holland, Frei and Emil Freireich later created another drug regimen for acute lymphoblastic leukemia (ALL) in children.

The combination of methotrexate, mercaptopurine, vincristine and prednisone – together known as the POMP regimen – produced sustained remission in these patients.

[8] After leaving Roswell Park, Holland spent several months conducting cancer research in the Soviet Union.

According to DeVita, Holland's influence ensured that childhood leukemia research received ongoing attention.

[13] Holland had a daughter, Diane Louise,[3] with his first wife, Fern Lucille Rahe, whom he married at Madison Avenue Presbyterian Church in June 1945.