[2] Hepburn was Treasurer of Scotland between from at least June 1515, until October the following year.

[2] He was elected Bishop of Moray sometime before 12 February 1516, on the nomination of the Governor of Scotland, John Stewart, Duke of Albany, following the translation of Bishop Andrew Forman to the Archbishopric of St Andrews.

[4] With his provision by Pope Leo X on 14 May 1516, he received a Bull exempting him from the metropolitan and legatine jurisdiction of the Archbishop of St Andrews.

[5] Although Archbishop Forman (d. 1521) had consented to this, his successor James Beaton resented it, and wrote to a senior Cardinal as a part of a wider attempt to have this reversed.

[5] Among other activities as during his short episcopate, Hepburn instituted the church of Duffus as a new rectory.