William de Spynie (died 1406) was a Scottish prelate.
By 1372 x 1373, he had exchanged the latter position with William Boyl for the Precentorship of Moray.
William de Spynie's episcopate, like that of his predecessor Alexander Bur's, suffered amid the political insecurity in this part of Scotland.
Alexander of Lochaber, brother of Domhnall of Islay, Lord of the Isles, had been using his role as "protector" of Moray, assigned to him by his brother and the absentee Earl, to further his own lordship.
This included granting episcopal lands to his military followers.